Nfl Week 6 Straight Up Picks 2025. You can bet on any of these games at draftkings. There’s almost an infinite way to bet on the nfl, from nfl picks against the spread, over/under, nfl parlays,.

For more week 6 picks, check out our nfl betting analyst iain macmillan’s best bet for every game on the slate here! Let’s take a look at where everyone stands through the first five weeks and then we’ll dive into our picks for week 6.